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Induction of VEGF-A expression by methylmercury is mediated by the EGFR–p38 MAPK–COX-2–PKA pathway in cultured human brain microvascular pericytes

Eiko Yoshida, Kenta Sakurai, Akishige Hirata, Tomoko Sasaoka, Takashi Hirooka, Tomoya Fujie, Takato Hara, Chika Yamamoto, Yasuyuki Fujiwara, Yo Shinoda, Komyo Eto, Toshiyuki Kaji

The Journal of Toxicological Science, 50, 199-204, 2025.

ヒト脳微小血管周皮細胞においてメチル水銀がEGFR-p38 MAPK-COX2-PKA経路を活性化させることでVEGFAを誘導することを明らかにしました。